Natural compounds from coffee beans exhibit potential anticancer properties, particularly in breast cancer treatment. This study investigates the effects of Arabica and Robusta coffee extracts on breast cancer cell lines, focusing on their ability to induce apoptosis and inhibit cell proliferation.
• Breast cancer remains a leading cause of cancer death among women, with new drug developments targeting cancer cells while sparing healthy ones.
• Coffee extracts, particularly those rich in chlorogenic acid, showed significant cytotoxic effects on MDA-MB-231 and MCF-7 breast cancer cells while exhibiting low toxicity to normal kidney cells.
• The study revealed that coffee extracts modulate the Wnt/β-catenin signaling pathway, leading to downregulation of MYC and AXIN2 genes, which are crucial for cancer cell growth and survival.
• Molecular docking and dynamics simulations indicated that chlorogenic acid binds effectively to Tankyrase-1, a key regulator in the Wnt pathway, supporting its role in promoting apoptosis in cancer cells.
Understanding the molecular mechanisms behind coffee's anticancer effects is vital for developing targeted therapies. The findings highlight coffee extracts' potential as complementary agents in breast cancer treatment, emphasizing the need for further research to validate these results.
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